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- REFINE DERMATOLOGY, KNOXVILLE, TN -

By Bob Berendsen January 21, 2026
By Dr. Jill Salyards, Owner & Founder of Refine Dermatology in Knoxville, Tennessee Skin cancer is the most common cancer in the United States, affecting millions of people each year. While that statistic can sound alarming, there is encouraging news: when detected early, skin cancer is one of the most treatable cancers. Early diagnosis and appropriate treatment play a critical role in protecting not only your skin but your overall health. At Refine Dermatology in Knoxville, Tennessee, we believe patient education is a powerful tool. Understanding what skin cancer looks like, the different types, and the treatment options available can help you feel more informed and empowered about your skin health. Why Skin Cancer Awareness Matters Your skin is your body’s largest organ, and it’s exposed to environmental factors—especially ultraviolet (UV) radiation—every single day. Over time, sun exposure can damage skin cells, leading to abnormal growth and, eventually, skin cancer. Routine skin checks, both at home and with a board-certified dermatologist, are essential for catching skin cancer early. Many skin cancers begin subtly, often appearing as small changes that are easy to overlook. Basal Cell Carcinoma: The Most Common Skin Cancer What Is Basal Cell Carcinoma? Basal cell carcinoma (BCC) is the most common type of skin cancer. It arises from the basal cells in the lower layer of the epidermis and typically develops in sun-exposed areas such as the face, neck, ears, and scalp. Although basal cell carcinoma rarely spreads to other parts of the body, it can continue to grow locally. If left untreated, it can cause significant tissue damage and, in some cases, affect nearby structures. What Does Basal Cell Carcinoma Look Like? Basal cell carcinoma can appear in several ways, including: ● A pearly or shiny bump ● A pink or flesh-colored patch that slowly enlarges ● A sore that doesn’t heal or repeatedly scabs over ● A small indentation with raised edges Treatment Options for Basal Cell Carcinoma Treatment depends on the size, depth, and location of the cancer. Common treatment options include: ● Surgical Excision: The cancer is removed along with a margin of healthy skin to ensure complete removal. ● Mohs Surgery: Mohs is a specialized, tissue-sparing technique often used for high-risk areas such as the nose, eyelids, ears, and lips. The cancer is removed layer by layer and examined under a microscope in real time, preserving as much healthy skin as possible. ● ED&C (Electrodesiccation and Curettage): For certain superficial basal cell carcinomas, the lesion is carefully scraped and cauterized. ● Topical Medications: In select cases, topical treatments such as imiquimod may be appropriate. Squamous Cell Carcinoma What Is Squamous Cell Carcinoma? Squamous cell carcinoma (SCC) is the second most common type of skin cancer. It develops from squamous cells, which make up the outer layer of the skin. While many squamous cell carcinomas are treatable, SCC carries a higher risk of spreading than basal cell carcinoma, especially when tumors are larger or located in high-risk areas. What Does Squamous Cell Carcinoma Look Like? Squamous cell carcinoma may appear as: ● Scaly or rough patches ● Crusted or wart-like bumps ● Tender or painful lesions ● Areas that bleed easily or don’t heal High-risk locations include the ears, lips, scalp, and hands. Treatment Options for Squamous Cell Carcinoma Treatment varies based on the tumor’s characteristics: ● Surgical Excision: Often the first-line treatment, especially for well-defined tumors. ● Mohs Surgery: Recommended for high-risk tumors, recurrent lesions, or cancers in cosmetically sensitive areas. ● ED&C or Topical Therapies: May be appropriate for early or superficial squamous cell carcinomas. ● Radiation Therapy or Systemic Treatment: In more advanced cases, treatment may involve radiation or collaboration with oncology specialists. Melanoma: The Most Serious Type of Skin Cancer What Is Melanoma? Melanoma is the most serious form of skin cancer because it can spread quickly to other parts of the body. It develops from melanocytes, the cells responsible for pigment in the skin. Early detection is absolutely critical for melanoma, as treatment outcomes are significantly better when caught early. What Does Melanoma Look Like? Melanoma often appears as a new or changing mole. Dermatologists commonly use the ABCDE rule to identify warning signs: ● A – Asymmetry: One half doesn’t match the other ● B – Border: Irregular, scalloped, or poorly defined edges ● C – Color: Multiple colors or uneven pigmentation ● D – Diameter: Larger than a pencil eraser (though smaller melanomas exist) ● E – Evolving: Changes in size, shape, or color Any mole or spot that looks different from others or changes over time should be evaluated. Treatment Options for Melanoma Treatment depends largely on the stage at diagnosis: ● Surgical Excision: Early-stage melanomas are treated with surgical removal, often with a wider margin of healthy skin. ● Sentinel Lymph Node Biopsy: For deeper melanomas, this procedure helps determine whether the cancer has begun to spread. ● Advanced Treatments: More advanced melanomas may require immunotherapy, targeted therapy, or radiation, typically in collaboration with oncology specialists. Actinic Keratosis: Precancerous Skin Lesions What is Actinic Keratosis? Actinic keratosis (AKs) are rough, scaly spots caused by cumulative sun damage. While they are not cancer, they are considered precancerous because they can progress into squamous cell carcinoma if left untreated. AKs commonly develop on the face, scalp, forearms, and hands. Treatment Options for Actinic Keratosis Managing actinic keratosis early is an important step in skin cancer prevention. Treatment options include: ● Cryotherapy: Freezing the lesions with liquid nitrogen. ● Topical Medications: Such as fluorouracil, which targets abnormal cells over a treatment period. ● Photodynamic Therapy (PDT): A light-based treatment designed to selectively destroy precancerous cells. The Importance of Early Detection and Regular Skin Exams While skin cancer is common, the good news is that early detection saves lives. Regular full-body skin exams allow dermatologists to identify suspicious lesions before they become more serious. You should schedule a professional skin exam if you notice: ● A new or changing spot ● A lesion that doesn’t heal ● A mole that looks different from others ● Any growth that bleeds, scabs, or feels tender Expert Skin Cancer Care in Knoxville, Tennessee At Refine Dermatology, our goal is to provide expert, compassionate care at every step—from screening and diagnosis to treatment and follow-up. As a board-certified dermatologist, I’m here to guide you through the process so you feel informed, supported, and confident in your care. If you have concerns about a spot on your skin or are due for a routine skin check, we encourage you to schedule an appointment. Your skin health today plays a vital role in your long-term well-being. Early detection makes all the difference!
Your Chemical Peel: What to Expect from Start to Finish | Refine Dermatology
By Bob Berendsen December 17, 2025
I’m Dr. Salyards of Refine Dermatology in Knoxville. Thinking about a chemical peel? Here’s what to expect before, during, and after treatment.
Botox, Dysport & Modern Anti-Aging | Refine Dermatology
By Bob Berendsen December 3, 2025
As one of the most popular treatments at Refine Dermatology in Knoxville, I want to walk through what neurotoxins are, how they work, and the treatment areas that make the biggest impact.
By refine December 16, 2022
In this blog, our dermatologist answers questions related to stretched, torn or gauged earlobes and how to repair them.
By refine December 6, 2022
At what age should I start going to see a dermatologist? There is no set age that anyone should start seeing a dermatologist and the answer can vary depending on your skin concerns, family history and skin type/color. A good rule of thumb is to establish care with a dermatologist in your 20s-30s. This allows your dermatologist to have a baseline examination of your skin and can make recommendations based on your examination. A dermatologist can also help prevent and reverse sun damage, so starting earlier can be beneficial and decrease your risk of skin cancer in the future.
By refine November 29, 2022
Below are a series of questions we get asked from patients that Dr. Salyards has answered. Hopefully this information is helpful and if you have any questions or would like to schedule an appointment call 865-545-0900 or email info@refinederm.com .
By refine November 21, 2022
Below are a series of questions we get asked from patients that Dr. Salyards has answered. Hopefully this information is helpful and if you have any questions or would like to schedule an appointment call 865-545-0900 or email info@refinederm.com .
By refine September 22, 2022
Millions of people experience acne. This common skin condition has several options for remedy, from changes in a skincare routine to topical creams. However, finding the best treatment option can be difficult.
By refine July 18, 2022
If you’re one of the many people who suffer from eczema, you know just how frustrating it can be, but you’re not alone. Eczema affects approximately 15 million people across America. Read on to learn more about an overview of eczema and learn some helpful tips for managing the condition.
By refine June 6, 2022
Over seven million American adults currently live with psoriasis. While there is no cure, understanding what psoriasis is and what causes it can help you live with the skin condition more comfortably.
Show More
By Bob Berendsen January 21, 2026
By Dr. Jill Salyards, Owner & Founder of Refine Dermatology in Knoxville, Tennessee Skin cancer is the most common cancer in the United States, affecting millions of people each year. While that statistic can sound alarming, there is encouraging news: when detected early, skin cancer is one of the most treatable cancers. Early diagnosis and appropriate treatment play a critical role in protecting not only your skin but your overall health. At Refine Dermatology in Knoxville, Tennessee, we believe patient education is a powerful tool. Understanding what skin cancer looks like, the different types, and the treatment options available can help you feel more informed and empowered about your skin health. Why Skin Cancer Awareness Matters Your skin is your body’s largest organ, and it’s exposed to environmental factors—especially ultraviolet (UV) radiation—every single day. Over time, sun exposure can damage skin cells, leading to abnormal growth and, eventually, skin cancer. Routine skin checks, both at home and with a board-certified dermatologist, are essential for catching skin cancer early. Many skin cancers begin subtly, often appearing as small changes that are easy to overlook. Basal Cell Carcinoma: The Most Common Skin Cancer What Is Basal Cell Carcinoma? Basal cell carcinoma (BCC) is the most common type of skin cancer. It arises from the basal cells in the lower layer of the epidermis and typically develops in sun-exposed areas such as the face, neck, ears, and scalp. Although basal cell carcinoma rarely spreads to other parts of the body, it can continue to grow locally. If left untreated, it can cause significant tissue damage and, in some cases, affect nearby structures. What Does Basal Cell Carcinoma Look Like? Basal cell carcinoma can appear in several ways, including: ● A pearly or shiny bump ● A pink or flesh-colored patch that slowly enlarges ● A sore that doesn’t heal or repeatedly scabs over ● A small indentation with raised edges Treatment Options for Basal Cell Carcinoma Treatment depends on the size, depth, and location of the cancer. Common treatment options include: ● Surgical Excision: The cancer is removed along with a margin of healthy skin to ensure complete removal. ● Mohs Surgery: Mohs is a specialized, tissue-sparing technique often used for high-risk areas such as the nose, eyelids, ears, and lips. The cancer is removed layer by layer and examined under a microscope in real time, preserving as much healthy skin as possible. ● ED&C (Electrodesiccation and Curettage): For certain superficial basal cell carcinomas, the lesion is carefully scraped and cauterized. ● Topical Medications: In select cases, topical treatments such as imiquimod may be appropriate. Squamous Cell Carcinoma What Is Squamous Cell Carcinoma? Squamous cell carcinoma (SCC) is the second most common type of skin cancer. It develops from squamous cells, which make up the outer layer of the skin. While many squamous cell carcinomas are treatable, SCC carries a higher risk of spreading than basal cell carcinoma, especially when tumors are larger or located in high-risk areas. What Does Squamous Cell Carcinoma Look Like? Squamous cell carcinoma may appear as: ● Scaly or rough patches ● Crusted or wart-like bumps ● Tender or painful lesions ● Areas that bleed easily or don’t heal High-risk locations include the ears, lips, scalp, and hands. Treatment Options for Squamous Cell Carcinoma Treatment varies based on the tumor’s characteristics: ● Surgical Excision: Often the first-line treatment, especially for well-defined tumors. ● Mohs Surgery: Recommended for high-risk tumors, recurrent lesions, or cancers in cosmetically sensitive areas. ● ED&C or Topical Therapies: May be appropriate for early or superficial squamous cell carcinomas. ● Radiation Therapy or Systemic Treatment: In more advanced cases, treatment may involve radiation or collaboration with oncology specialists. Melanoma: The Most Serious Type of Skin Cancer What Is Melanoma? Melanoma is the most serious form of skin cancer because it can spread quickly to other parts of the body. It develops from melanocytes, the cells responsible for pigment in the skin. Early detection is absolutely critical for melanoma, as treatment outcomes are significantly better when caught early. What Does Melanoma Look Like? Melanoma often appears as a new or changing mole. Dermatologists commonly use the ABCDE rule to identify warning signs: ● A – Asymmetry: One half doesn’t match the other ● B – Border: Irregular, scalloped, or poorly defined edges ● C – Color: Multiple colors or uneven pigmentation ● D – Diameter: Larger than a pencil eraser (though smaller melanomas exist) ● E – Evolving: Changes in size, shape, or color Any mole or spot that looks different from others or changes over time should be evaluated. Treatment Options for Melanoma Treatment depends largely on the stage at diagnosis: ● Surgical Excision: Early-stage melanomas are treated with surgical removal, often with a wider margin of healthy skin. ● Sentinel Lymph Node Biopsy: For deeper melanomas, this procedure helps determine whether the cancer has begun to spread. ● Advanced Treatments: More advanced melanomas may require immunotherapy, targeted therapy, or radiation, typically in collaboration with oncology specialists. Actinic Keratosis: Precancerous Skin Lesions What is Actinic Keratosis? Actinic keratosis (AKs) are rough, scaly spots caused by cumulative sun damage. While they are not cancer, they are considered precancerous because they can progress into squamous cell carcinoma if left untreated. AKs commonly develop on the face, scalp, forearms, and hands. Treatment Options for Actinic Keratosis Managing actinic keratosis early is an important step in skin cancer prevention. Treatment options include: ● Cryotherapy: Freezing the lesions with liquid nitrogen. ● Topical Medications: Such as fluorouracil, which targets abnormal cells over a treatment period. ● Photodynamic Therapy (PDT): A light-based treatment designed to selectively destroy precancerous cells. The Importance of Early Detection and Regular Skin Exams While skin cancer is common, the good news is that early detection saves lives. Regular full-body skin exams allow dermatologists to identify suspicious lesions before they become more serious. You should schedule a professional skin exam if you notice: ● A new or changing spot ● A lesion that doesn’t heal ● A mole that looks different from others ● Any growth that bleeds, scabs, or feels tender Expert Skin Cancer Care in Knoxville, Tennessee At Refine Dermatology, our goal is to provide expert, compassionate care at every step—from screening and diagnosis to treatment and follow-up. As a board-certified dermatologist, I’m here to guide you through the process so you feel informed, supported, and confident in your care. If you have concerns about a spot on your skin or are due for a routine skin check, we encourage you to schedule an appointment. Your skin health today plays a vital role in your long-term well-being. Early detection makes all the difference!
Your Chemical Peel: What to Expect from Start to Finish | Refine Dermatology
By Bob Berendsen December 17, 2025
I’m Dr. Salyards of Refine Dermatology in Knoxville. Thinking about a chemical peel? Here’s what to expect before, during, and after treatment.
Botox, Dysport & Modern Anti-Aging | Refine Dermatology
By Bob Berendsen December 3, 2025
As one of the most popular treatments at Refine Dermatology in Knoxville, I want to walk through what neurotoxins are, how they work, and the treatment areas that make the biggest impact.
By refine December 16, 2022
In this blog, our dermatologist answers questions related to stretched, torn or gauged earlobes and how to repair them.
By refine December 6, 2022
At what age should I start going to see a dermatologist? There is no set age that anyone should start seeing a dermatologist and the answer can vary depending on your skin concerns, family history and skin type/color. A good rule of thumb is to establish care with a dermatologist in your 20s-30s. This allows your dermatologist to have a baseline examination of your skin and can make recommendations based on your examination. A dermatologist can also help prevent and reverse sun damage, so starting earlier can be beneficial and decrease your risk of skin cancer in the future.
By refine November 29, 2022
Below are a series of questions we get asked from patients that Dr. Salyards has answered. Hopefully this information is helpful and if you have any questions or would like to schedule an appointment call 865-545-0900 or email info@refinederm.com .
By refine November 21, 2022
Below are a series of questions we get asked from patients that Dr. Salyards has answered. Hopefully this information is helpful and if you have any questions or would like to schedule an appointment call 865-545-0900 or email info@refinederm.com .
By refine September 22, 2022
Millions of people experience acne. This common skin condition has several options for remedy, from changes in a skincare routine to topical creams. However, finding the best treatment option can be difficult.
By refine July 18, 2022
If you’re one of the many people who suffer from eczema, you know just how frustrating it can be, but you’re not alone. Eczema affects approximately 15 million people across America. Read on to learn more about an overview of eczema and learn some helpful tips for managing the condition.
By refine June 6, 2022
Over seven million American adults currently live with psoriasis. While there is no cure, understanding what psoriasis is and what causes it can help you live with the skin condition more comfortably.
Show More