Microneedling

PRFM Microneedling

- Refine Dermatology, Knoxville, TN -

Advanced Regenerative Skin Rejuvenation at Refine Dermatology

At Refine Dermatology, we are committed to offering the most advanced, evidence-based treatments available. We are proud to offer Microneedling with PRFM (Platelet-Rich Fibrin Matrix) — the next evolution of traditional PRP microneedling, also known as the Vampire Facial.



This enhanced regenerative treatment improves skin texture, tone, fine lines, acne scars, and overall radiance with science-backed, natural collagen stimulation using your body’s own natural growth factors — delivered in a more powerful and longer-lasting form than traditional PRP.

What Is PRFM? (And How Is It Different from PRP?)

PRFM (Platelet-Rich Fibrin Matrix) is an advanced version of PRP (Platelet-Rich Plasma).

While traditional PRP releases growth factors quickly after injection, PRFM forms a fibrin matrix that:

• Stabilizes and protects platelets
• Creates a scaffold supporting stronger tissue regeneration
• Allows for slower, sustained release of growth factors
• Enhances collagen stimulation

This means more consistent collagen remodeling and longer-lasting regenerative effects than traditional PRP.


How Microneedling with PRFM Works

  1. A small amount of your blood is drawn.
  2. It is processed using a specialized system to create PRFM.
  3. Microneedling creates controlled microchannels in the skin.
  4. PRFM is applied and delivered into the skin through these channels.

This combination stimulates collagen, elastin, and cellular repair improving skin quality from within.


Why We Chose PRFM Over PRP

At Refine Dermatology, we continually evaluate the science behind every treatment we offer.

PRFM provides:

• More stable platelet concentration
• Reduced inflammatory breakdown
• Prolonged growth factor release
• More predictable regenerative response

For patients, this means optimized outcomes with the same natural, autologous approach.


What Concerns Can It Treat?

Microneedling with PRFM is ideal for:

• Fine lines and early aging
• Acne scars
• Uneven texture
• Enlarged pores
• Dull skin
• Crepey skin (face, neck, décolletage)
• Mild skin laxity


What to Expect

Downtime is minimal. Most patients experience redness similar to a mild sunburn for 24–48 hours.

A series of 3 treatments spaced 4–6 weeks apart is typically recommended for optimal collagen remodeling.

Results develop gradually as your skin produces new collagen over the following weeks.


Is PRFM Safe?

Yes. Because PRFM is derived from your own blood, there is minimal risk of allergic reaction. It is a natural, regenerative approach to skin rejuvenation.

All treatments at Refine Dermatology are performed under the supervision of a board-certified dermatologist to ensure safety and optimal outcomes.


Frequently Asked Questions About PRFM Microneedling

Is PRFM better than PRP?

PRFM provides a more stable platelet concentration and slower growth factor release compared to traditional PRP, which may lead to more consistent regenerative outcomes.

How long do results last?

Results vary, but improvements in texture and firmness can continue developing for several months following treatment.

Is this the same as a vampire facial?

PRFM microneedling is an advanced form of the popular “vampire facial,” using a more refined regenerative matrix instead of traditional PRP.

Can PRFM help acne scars?

Yes. PRFM microneedling is an excellent treatment for acne scars in patients looking for collagen remodeling without surgery.


Ready to Elevate Your Skin?

If you are looking for natural rejuvenation with advanced regenerative science, Microneedling with PRFM may be right for you.

Schedule a cosmetic consultation today to learn if this treatment fits your goals.



If you’d like to discuss cosmetics further, please feel free to give us a call or contact us by filling out our cosmetic survey and we’ll reach out to you by the next business day to schedule you with Dr. Salyards or Bailey Chitwood.